Autophagy Machinary Components:
Genes Involved in Autophagic Vacuole Formation:
AMBRA1, ATG12, ATG16L1, ATG4A, ATG4B, ATG4C, ATG4D, ATG5, ATG9A, ATG9B,
BECN1, GABARAP, GABARAPL1, GABARAPL2, IRGM, MAP1LC3A, MAP1LC3B, RGS1,
ULK1.
Genes Responsible for Protein Targeting to Membrane / Vacuole: ATG4A, ATG4B, ATG4C, ATG4D, GABARAP.
Genes Responsible for Protein Transport: ATG10, ATG16L1, ATG16L2, ATG3, ATG4A, ATG4B, ATG4C, ATG4D, ATG7, ATG9A, GABARAP, GABARAPL2, RAB24.
Genes Linking Autophagosome to Lysosome: DRAM, GABARAP, TMEM166.
Genes Involved in Protein Ubiquitination: ATG3, ATG7.
Genes with Protease Activity: ATG4A, ATG4B, ATG4C, ATG4D.
Regulation of Autophagy:
Co-Regulators of Autophagy and Apoptosis:
AKT1, APP, ATG12, ATG5, BAD, BAK1, BAX, BCL2, BCL2L1, BECN1, BID,
BNIP3, CASP3, CASP8, CDKN1B, CDKN2A, CLN3, CTSB, CXCR4, DAPK1, DRAM,
EIF2AK3, FADD, FAS, HDAC1, HTT, IFNA2, IFNG, IGF1, INS, MAPK8, NFKB1,
PIK3CG, PRKAA1, PTEN, SNCA, SQSTM1, TGFB1, TGM2, TNF, TNFSF10, TP53,
TP73.
Co-Regulators of Autophagy and the Cell Cycle: BAX, CDKN1B, CDKN2A, IFNG, PTEN, RB1, TGFB1, TP53, TP73.
Autophagy Induction by Intracellular Pathogens: EIF2AK3, IFNA2, IFNA4, IFNG.
Autophagy in Response to Other Intracellular Signals: ARSA, CTSS, EIF4G1, ESR1, GAA, HGS, MAPK14, PIK3C3, PIK3R4, PRKAA2, RPS6KB1, TMEM74, TMEM77, ULK2, UVRAG.
Chaperone-Mediated Autophagy: HSP90AA1, HSPA8.
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